Sophos have announced that their Anti-virus product will be offered for free to HP Integrity Server customers, and it runs on OpenVMS.
If you store files or emails for MS Windows on your OpenVMS system then you may find running anti-virus software on OpenVMS useful.
Sophos Anti-Virus for UNIX provides integrated cross-platform virus and spyware detection on non-Windows servers.
More information on this offer is available in the press release - Sophos malware protection now available to HP Integrity server customers